Maxfacts

Bleeding

Textbooks

J. Harenberg, D.L. Heene, G. Stehle and G. Schettler (eds.). New Trends in Haemostasis: Coagulation Proteins, Endothelium, and Tissue Factors. Springer Verlag, Heidelberg Berlin, 1990.

N.S. Hakim and R. Canelo (eds.). Haemostasis in Surgery. Imperial College Press, London, 2007.

J.P. Antovic and M. Blombäck (eds.). Essential Guide to Blood Coagulation. Wiley-Blackwell, Chichester, 2013.

C. Scully. Medical Problems in Dentistry, 6^th edition. Churchill-Livingstone, London, 2010.

D.N. Granger and J. Granger (Series eds.). Colloquium Series in Integrated Systems Physiology: from Molecule to Function. Part 1, The Endothelium. M. Félétou. Multiple Functions of the Endothelial Cells—Focus on

Endothelium-Derived Vasoactive Mediators; S.Y. Yuan and R.R. Rigor. Regulation of Endothelial Barrier Function. Morgan & Claypool, California, 2011.

A.D. Michelson (ed.). Platelets, 4^th edition. Academic Press, London, 2019.

Journal articles (peer reviewed literature)

B.V. Bajkin, I.A. Bajkin and B.B. Petrovic. The effects of combined oral anticoagulant-aspirin therapy in patients undergoing tooth extractions; a prospective study. Journal of the American Dental Association 143, 771-775 (2012).

T. Lillis et al. Safety of dental extractions during uninterrupted single or dual antiplatelet treatment. American Journal of Cardiology 108, 964-967 (2011).

Y. Morimoto, H. Niwa and K. Minematsu. Risk factors affecting postoperative hemorrhage after tooth extraction in patients receiving oral antithrombotic therapy. Journal of Oral and Maxillofacial Surgery 69, 1550-1556 (2011).

R.A. Powless et al. Management of antithrombotic therapy before full-mouth extraction. Journal of the Californian Dental Association 41, 417-420 (2013).

D.S. Celermajer. Endothelial Dysfunction: Does It Matter? Is It Reversible? Journal of the American College of Cardiology 30, 325-33 (1997).

G. D’Andrea, M. Chetta and M. Margaglione. Inherited platelet disorders: thrombocytopenias and thrombocytopathies. Blood Transfusion 7, 278-292 (2009).

Y. Brennan, M. Levade and C.M. Ward. Acquired platelet function disorders. Thrombosis Research, in press (2019). doi.org/10.1016/j.thromres.2019.06.009

M. Schlesinger. Role of platelets and platelet receptors in cancer metastasis. Journal of Hematology and Oncology 11, 125 (2018).

M. Bryckaert et al. Of von Willebrand factor and platelets. Cellular and Molecular Life Sciences 72, 307-326 (2015).

M.E. Jaax et al. Complex formation with nucleic acids and aptamers alters the antigenic properties of platelet factor 4. Blood 122, 272-281 (2013).

T. Thiele and A. Greinacher. Platelet Transfusion in Perioperative Medicine. Seminars in Thrombosis and Hemostasis 46, 050-061 (2020).

Y. Zhao, P.M. Vanhoutte and S.W.S. Leung. Vascular nitric oxide: Beyond eNOS. Journal of Pharmacological Sciences 129, 83-94 (2015).

A. Sandoo et al. The Endothelium and Its Role in Regulating Vascular Tone. Open Cardiovascular Medicine Journal 4, 302-312 (2010).

P. Rajendran et al. The Vascular Endothelium and Human Diseases. International Journal of Biological Sciences 9, 1057-1069 (2013).

Extreme temperatures

Textbooks

K.K. Desarda. Cryosurgery. Clinical Applications in Otorhinolaryngology. Jaypee, New Delhi, 2013.

N.N. Korpan (ed.). Basics of Cryosurgery. Springer Verlag, Wien, 2012.

P.Pasquali (ed.). Cryosurgery. A Practical Manual. Springer, Heidelberg New York, 2015.

S. Namour. Atlas of Current Oral Laser Surgery. Universal Publishers, Boca Raton, 2011.

V. Oswal and M. Remacle (eds.). Principles and Practice of Lasers in Otorhinolaryngology and Head and Neck Surgery, 2^nd edition. Kugler Publications, Amsterdam, 2014.

Journal articles (peer reviewed literature)

P.U. Abdul Wahab et al. Scalpel Versus Diathermy in Wound Healing After Mucosal Incisions: A Split-Mouth Study. Journal of Oral and Maxillofacial Surgery 76, 1160-1164 (2018).

D. Schneider et al. Use of ultrasonic scalpel and monopolar electrocautery for skin incisions in neck dissection: a prospective randomized trial. Oral and Maxillofacial Surgery 22, 169-175 (2018).

A.M. Trescot. Cryoanalgesia in Interventional Pain Management. Pain Physician 6, 345-360 (2003).

N.N. Massarweh, N. Cosgriff and D.P. Slakey. Electrosurgery: history, principles, and current and future uses. Journal of the American College of Surgeons 202, 520-530 (2006).

M. Karjalainen et al. The characterization of surgical smoke from various tissues and its implications for occupational safety. PLOS ONE 13: e0195274 (2018).

J. Reichelt et al. A novel blue light laser system for surgical applications in dentistry: evaluation of specific laser-tissue interactions in monolayer cultures. Clinical Oral Investigations 21, 985-994 (2017).

P.F. Bradley. A review of the use of the neodymium YAG laser in oral and maxillofacial surgery. British Journal of Oral and Maxillofacial Surgery 35, 26-35 (1997).

L. Carroll and T.R Humphreys. LASER – tissue interactions. Clinics in Dermatology 24, 2-7 (2006).

M.M. Jawad et al. An Overview of Laser Principles, Laser-Tissue Interaction Mechanisms and Laser Safety Precautions for Medical Laser Users. International Journal of Pharmacology 7, 149-170 (2011).

F.W. Neukam and F. Stelzle. Laser Tumor Treatment in Oral and Maxillofacial Surgery. Physcis Procedia 5, 91-100 (2010).

G. Ilaria et al. Advantages of new technologies in oral mucosal surgery: an intraoperative comparison among Nd:YAG laser, quantic molecular resonance scalpel, and cold blade. Lasers in Medical Science 30, 1903-1910 (2015).

E. Schena, P. Saccomandi and Y. Fong. Laser Ablation for Cancer: Past, Present and Future. Journal of Functional Biomaterials 8, 19-34 (2017).

Hyperbaric oxygen

Electronic resources

Information about the HOPON and DAHNCA21 clinical trials can be found at www.lctu.org.uk/

Textbooks

T.S. Neumann and S.R. Thom (eds.). Physiology and Medicine of Hyperbaric Oxygen Therapy. Elsevier, Philadelphia, 2008.

L.K. Weaver (ed.). Hyperbaric Oxygen Therapy Indications: The Hyperbaric Oxygen Therapy Committee Report. Best Publishing Company, 2014.

Journal articles (peer reviewed literature)

L. Spiegelberg, U.M. Djasim, H.W. van Neck, E.B. Wolvius and K.G. van der Waal. Hyperbaric oxygen therapy in the management of radiation-induced injury in the head and neck region: a review of the literature. Journal of Oral and Maxillofacial Surgery 68, 1732-1739 (2010).

J. Dhanda, D. Pasquier, L. Newman and R. Shaw. Current Concepts in Osteoradionecrosis after Head and Neck Radiotherapy. Clinical Oncology, 28, 459-466 (2016).

S.N. Rogers, J.J. D’Souza, D. Lowe and A. Kanatas. Longitudinal evaluation of health-related quality of life after osteoradionecrosis of the mandible. British Journal of Oral and Maxillofacial Surgery 53, 854-857 (2015).

R. Shaw et al. Refining the definition of mandibular osteoradionecrosis in clinical trials: The cancer research UK HOPON trial (Hyperbaric Oxygen for the Prevention of Osteoradionecrosis). Oral Oncology 64, 73-77 (2017).

F.J. Dieleman et al. The efficacy of hyperbaric oxygen therapy related to the clinical stage of osteoradionecrosis of the mandible. International Journal of Oral and Maxillofacial Surgery 46, 428-433 (2017).

A. Sultan et al. The Use of Hyperbaric Oxygen for the Prevention and Management of Osteoradionecrosis of the Jaw: A Dana-Farber/Brigham and Women’s Cancer Center Multidisciplinary Guideline. The Oncologist 22, 343-350 (2017).

T. Sønstevold et al. Hyperbaric oxygen treatment did not significantly affect radiation injury in the mandibular area of rats. Oral and Maxillofacial Surgery 125, 112-119 (2018).

Medication

Textbooks

T. Tozer and M. Rowland. Introduction to Pharmacokinetics and Pharmacodynamics: The Quantitative Basis of Drug Therapy. Lippincott Williams & Wilkins, Baltimore, 2006.

M. Winter. Basic Clinical Pharmacokinetics. Lippincott Williams & Wilkins, Philadelphia, 2004.

R. Anderson, P. Groundwater, A. Todd and A. Worsley. Antibacterial Agents: Chemistry, Mode of Action, Mechanisms of Resistance. Wiley, Chichester, 2012.

M. Gotte, A. Berghuis, G. Matlashewski, M. Wainberg and D. Sheppard (eds.). Handbook of Antimicrobial Resistance. Springer, New York, 2018.

D.L. Mayers, J.D. Sobel, M. Ouellette, K.S. Kaye and D. Marchaim (eds.). Antimicrobial Drug Resistance: Mechanisms of Drug Resistance, Volume 1. Springer International Publishing, 2017.

D.L. Mayers, J.D. Sobel, M. Ouellette, K.S. Kaye and D. Marchaim (eds.). Antimicrobial Drug Resistance: Clinical and Epidemiological Aspects, Volume 2. Springer International Publishing, 2017.

V. Kumar, A.K. Abbas and J.C. Aster (eds.) Robbins and Cotran’s Pathologic Basis of Disease, 9^th edition. Elsevier, Philadephia, 2015.

J.E. Hall. Guyton and Hall Textbook of Medical Physiology, 13^th edition. Elsevier, Philadelphia, 2016.

G.L. Patrick. An Introduction to Medicinal Chemistry, 5^th edition. Oxford University Press, Oxford, 2013.

M.M. Dale and D.G Haylett. Pharmacology condensed, 2^nd edition. Elsevier, 2009.

B. Alberts, D. Bray, K. Hopkin, A.D. Johnson, J. Lewis, M. Raff, K. Roberts and P. Walter. Essential Cell Biology, 4^th edition. Taylor and Francis, 2013.

M.J. Neal. Medical pharmacology at a glance, 8^th edition. Wiley, 2015.

S.B. McMahon, M. Koltzenburg, I. Tracey and D. Turk (eds.). Wall and Melzack’s Textbook of Pain, 6^th edition. Elsevier, Philadelphia, 2013.

P. Beaulieu. D. Lussier, F. Porreca and A. Dickenson. Pharmacology of Pain. Lippincott Williams & Wilkins, 2015.

H. Lodish, A. Berk, C.A. Kaiser, M. Krieger, A. Bretscher, H. Ploegh, A. Amon and M.P. Scott. Molecular Cell Biology, 7^th edition. W. H. Freeman and Company, New York, 2012.

K. Turksen (ed.). Wound Healing: Stem Cells Repair and Restorations, Basic and Clinical Aspects. Wiley Blackwell, Hoboken, 2018.

P. Bennett, M.J. Brown and P. Sharma (eds.). Clinical Pharmacology, 11^th edition. Elsevier, Philadelphia, 2012.

P.J. Delves, S.J. Martin, D.R. Burton and I. M. Roitt. Roitt’s essential immunology. John Wiley and Sons, Chichester, 2017.

A.W. Thomson (ed.). Immunosuppression. Springer Science and Business Media, Dordrecht, 2001.

M. Peakman and D. Vergani. Basic and Clinical Immunology, 2^nd edition. Churchill Livingstone Elsevier, 2009.

M. Oellerich and A. Dasgupta (eds.). Personalized Immunosuppression in Transplantation. Role of Biomarker Monitoring and Therapeutic Drug Monitoring. Elsevier, Amsterdam, 2016.

C. Gersch, N.M. Heimgartner, C.R. Rebar and L.M Willis. Pharmacology made incredibly easy, 4^th edition. Wolters Kluwer Health, Philadelphia, 2017.

J.L. Cohen, D.M. Ozog and D.A. Porto (eds.). Botulinum Toxins: Cosmetic and Clinical Applications. Wiley, Blackwell, 2017.

B. Jabbari (ed.). Botulinum Toxin Treatment in Clinical Medicine. A Disease-Oriented Approach. Springer International Publishing, 2018.

K. Hashimoto, S. Ide and K. Ikeda (eds.). Ketamine: From Abused Drug to Rapid-Acting Antidepressant. Springer Singapore, 2020.

C. McGreal. American Overdose. Faber & Faber, London, 2018.

Electronic resources

European Medicines Agency, EMA; www.ema.europa.eu

Journal articles (peer reviewed literature)

A.W. Newman and S.R. Bryn. Solid-state analysis of the active pharmaceutical ingredient in drug products. Drug Discovery Today 8, 898-905 (2003).

R. Censi and P. di Martino. Polymorph Impact on Bioavailability and Stability of Poorly Soluble Drugs. Molecules 20, 18759-18776 (2015).

J.-C. Leroux. Drug Delivery: Too Much Complexity, Not Enough Reproducibility? Angewandte Chemie International Edition 56, 2-4 (2017).

J. Nemeth, G. Oesch and S.P. Kuster. Bacteriostatic versus bactericidal antibiotics for patients with serious bacterial infections: systematic review and meta-analysis. Journal of Antimicrobial Chemotherapy 70, 382-395 (2015).

D.N. Wilson. Ribosome-targeting antibiotics and mechanisms of bacterial resistance. Nature Reviews 12, 35-48 (2014).

H.C. Neu. The Crisis in Antibiotic Resistance. Science 257, 1064-1073 (1992).

J.M.A. Blair et al. Molecular mechanisms of antibiotic resistance. Nature Reviews Microbiology 13, 42-51 (2015).

S. Garneau-Tsodikovaa and K.J. Labby. Mechanisms of resistance to aminoglycoside antibiotics: Overview and perspectives. Medicinal Chemistry Communications 7, 11-27 (2016).

E. Bekerman and S. Einav. Combating emerging viral threats. Science 348, 282-283 (2015).

D. Montelongo-JaureguiI et al. Convalescent serum therapy for COVID-19: A

19th century remedy for a 21st century disease. PLoS Pathogens 16: e1008735 (2020).

Y. Chen et al. A comprehensive, longitudinal analysis of humoral responses specific to four recombinant antigens of SARS-CoV-2 in severe and non-severe COVID-19 patients. PLoS Pathogens 16: e1008796 (2020).

P. Doshi. Covid-19: Do many people have pre-existing immunity? British Medical Journal 370, m3563 (2020).

E.J. Haas et al. Impact and effectiveness of mRNA BNT162b2 vaccine against SARS-CoV-2 infections and COVID-19 cases, hospitalisations, and deaths following a nationwide vaccination campaign in Israel: an observational study using national surveillance data. The Lancet 397, 1819-1829 (2021).

E. Vasileiou et al. Effectiveness of First Dose of COVID-19 Vaccines Against Hospital Admissions in Scotland: National Prospective Cohort Study of 5.4 Million People. The Lancet, in press (2021).

P. Nordström, M. Ballin, and A. Nordström. Effectiveness of Covid-19 Vaccination Against Risk of Symptomatic Infection, Hospitalization, and Death Up to 9 Months: A Swedish Total-Population Cohort Study. The Lancet, in press (2021).

L.J. Abu-Raddad and A.A. Butt. Effectiveness of the BNT162b2 Covid-19 Vaccine against the B.1.1.7 and B.1.351 Variants. New England Journal of Medicine, DOI: 10.1056/NEJMc2104974 (2021).

T.T. Shimabukuro et al. Preliminary Findings of mRNA Covid-19 Vaccine Safety in Pregnant Persons. New England Journal of Medicine, DOI: 10.1056/NEJMoa2104983 (2021).

L.-A. Linkins. Heparin induced thrombocytopenia. British Medical Journal 350, g7566 (2015).

M.E. Jaax et al. Complex formation with nucleic acids and aptamers alters the antigenic properties of platelet factor 4. Blood 122, 272-281 (2013).

T.E. Warkentin. High-dose intravenous immunoglobulin for the treatment and prevention of heparin-induced thrombocytopenia: a review. Expert Review of Hematology 12, 685-698 (2019).

J.A. Dougherty and R.L. Yarsley. Intravenous Immune Globulin (IVIG) for Treatment of Autoimmune Heparin-Induced Thrombocytopenia: A Systematic Review. Annals of Pharmacotherapy 55, 198-215 (2021).

F. Kabinger et al. Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis. Nature Structural & Molecular Biology 28, 740-746 (2021).

A. Greinacher et al. Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination. New England Journal of Medicine 384, 2092-2101 (2021).

M. Othman et al. Adenovirus-induced thrombocytopenia: the role of von Willebrand factor and P-selectin in mediating accelerated platelet clearance. Blood 109, 2832-2839 (2007).

A. Greinacher et al. Towards Understanding ChAdOx1 nCov-19 Vaccine-induced Immune Thrombotic Thrombocytopenia (VITT). preprint at: https://www.researchsquare.com/article/rs-440461/v1

J. Greenhow Kelton, D. M. Arnold and I. Nazy. Lessons from vaccine-induced immune thrombotic thrombocytopenia. Nature Reviews Immunology doi.org/10.1038/s41577-021-00642-8 (2021).

F.C. Odds, A.J.P. Brown and N.A.R. Gow. Antifungal agents: mechanisms of action. Trends in Microbiology 11, 272-279 (2003).

L.E. Cowen et al. Mechanisms of Antifungal Drug Resistance. Cold Spring Harbor Perspectives in Medicine 5, 1-21 (2015).

A.K. Bartella et al. Prospective comparison of perioperative antibiotic management protocols in oncological head and neck surgery. Journal of Cranio-Maxillo-Facial Surgery 45, 1078-1082 (2017).

N.X. Landén, D. Li and M. Stähle. Transition from inflammation to proliferation: a critical step during wound healing. Cellular and Molecular Life Sciences 73, 3861-3885 (2016).

M.J. Porton et al. The innate immune system, toll-like receptors and dermal wound healing: A review. Vascular Pharmacology 71, 31-36 (2015).

S. Chattopadhyay and R.T. Raines. Collagen-Based Biomaterials for Wound Healing. Biopolymers 101, 821-823 (2014).

M. Karin and H. Clevers. Reparative inflammation takes charge of tissue regeneration. Nature 529, 307-315 (2016).

J.W. Godwin, A.R. Pinto and N.A. Rosenthal. Chasing the recipe for a pro-regenerative immune system. Seminars in Cell & Developmental Biology 61, 71-79 (2017).

A.T. Nurden. The biology of the platelet with special reference to inflammation, wound healing and immunity. Frontiers in Bioscience, Landmark Edition 23, 726-751 (2018).

J. Folkman et al. Tumor Angiogenesis – Therapeutic Implications. New England Journal of Medicine 285, 1182-1186 (1971).

E.C. Hayden. Cutting off cancer’s supply lines. Nature 458, 686-691 (2009).

H. Abdel-Qadir et al. Cardiovascular toxicity of angiogenesis inhibitors in treatment of malignancy: A systematic review and meta-analysis. Cancer Treatment Reviews 53, 120-127 (2017).

F. Elice and F. Rodeghiero. Side effects of anti-angiogenic drugs. Thrombosis Research 129, S50-S53 (2012).

J. Parkin and B. Cohen. An overview of the immune system. Lancet 357, 1777-1789 (2001).

R. Medzhitov. Recognition of microorganisms and activation of the immune response. Nature 449, 819-826 (2007).

A. Iwasaki and R. Medzhitov. Regulation of adaptive immunity by the innate immune system. Science 327, 291-295 (2010).

A. Mantovani, M.A. Cassatella, C. Constantini and S. Janillon. Neutrophils in the activation and regulation of innate and adaptive immunity. Nature Reviews Immunology 11, 519-531 (2011).

L. Koenderman, W. Buurman and M.R. Daha. The innate immune response. Immunology Letters 162, 95-102 (2014).

F. Estelle and R. Simmons. Advances in H1-Antihistamines. New England Journal of Medicine 351, 2203-2217 (2004).

P.J. Burnes. How corticosteroids control inflammation - Quintiles prize lecture 2005. British Journal of Pharmacology 148, 245-254 (2006).

I. Tabas and C.K. Glass. Anti-inflammatory therapy in chronic disease: challenges and opportunities. Science 339, 166-172 (2013).

H.A. Chakkera, A. Sharif and B. Kaplan. Negative Cardiovascular Consequences of Small Molecule Immunosuppressants. Clinical Pharmacology & Therapeutics 102, 269-278 (2017).

L. Saliba et al. Tumor necrosis factor inhibitors added to nonbiological immunosuppressants vs. nonbiological immunosuppressants alone: a different signal of cancer risk according to condition. A disproportionality analysis in a nationwide pharmacovigilance database. Fundamental & Clinical Pharmacology 30, 162-171 (2016).

O. Ethgen et al. What do we know about the safety of corticosteroids in rheumatoid arthritis? Current Medical Research and Opinion 29, 1147-1160 (2013).

J. Glyn. The discovery and early use of cortisone. Journal of the Royal Society of Medicine 91, 513-517 (1998).

J.R. Curtis et al. Population-based assessment of adverse events associated with long-term glucocorticoid use. Arthritis and Rheumatology 55, 420-426 (2006).

C. Antoni and J. Braun. Side effects of anti-TNF therapy: current knowledge. Clinical and Experimental Rheumatology 20, S152-S157 (2002).

T. Bongartz et al. Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials. The Journal of the American Medical Association 295, 2275-2285 (2006).

W. Chen et al. The tumor necrosis factor receptor superfamily member 1B polymorphisms predict response to anti-TNF therapy in patients with autoimmune disease: a meta-analysis. International Immunopharmacology 28, 146-153 (2015).

J.P.A. Ioannidis et al. Biologic agents in rheumatology: unmet issues after 200 trials and $200 billion sales. Nature Reviews Rheumatology 9, 665-673 (2013).

S. Pestka. The interferons: 50 years after their discovery, there is much more to learn. Journal of Biological Chemistry 282, 20047-20051 (2007).

L.C. Platanias. Mechanisms of type-I- and type-II-interferon-mediated signalling. Nature Reviews Immunology 5, 375-386 (2005).

L.B. Ivashkiv and G.D. Kalliolias. Overview of the biology of type I interferons. Arthritis Research & Therapy 12, S1 (2010).

B.S. Parker, J. Rautela and P.J. Hertzog. Antitumour actions of interferons: implications for cancer therapy. Nature Reviews Cancer 16, 131-144 (2016).

P. Gotwals et al. Prospects for combining targeted and conventional cancer therapy with immunotherapy. Nature Reviews Cancer 17, 286-301 (2017).

P. Hubel et al. A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape. Nature Immunology 20, 493-502 (2019).

R. Baron, A. Binder and G. Wasner. Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment. Lancet Neurology 9, 807-819 (2010).

P. Coulthard et al. Interventions for iatrogenic inferior alveolar and lingual nerve injury (Review). The Cochrane Collaboration (2014).

P. Cherian et al. Oral antibiotics versus topical decolonization to prevent surgical site infection after Mohs micrographic surgery: a randomized controlled trial. Dermatologic Surgery 39, 1486-1493 (2013).

M.H. Ossipov et al. Central modulation of pain. The Journal of Clinical Investigation 120, 3779-3787 (2010).

M. de Felice and M.H. Ossipov. Cortical and subcortical modulation of pain. Pain Management 6, 111-120 (2016).

M.H. Ossipov, K. Morimura and F. Porreca. Descending pain modulation and chronification of pain. Current Opinion in Supportive and Palliative Care 8, 143-151 (2014).

A.E. Dubin and A. Patapoutian. Nociceptors: the sensors of the pain pathway. The Journal of Clinical Investigation 120, 3760-3772 (2010).

C. Nasri-Heir et al. Altered pain modulation in patients with persistent postendodontic pain. Pain 156, 2032-2041 (2015).

C.J. Woolf. Central sensitization: Implications for the diagnosis and treatment of pain. Pain 152, S2-S15 (2011).

C.J. Woolf. What is this thing called pain? The Journal of Clinical Investigation 120, 3742-3744 (2010).

G. Vargas-Schaffer. Is the WHO analgesic ladder still valid? Canadian Family Physician 56, 514-517 (2010).

J.C. Ballantyne, E. Kalso and C. Stannard. WHO analgesic ladder: a good concept gone astray. British Medical Journal 352:i20 (2016).

M.J. Millan. Descending control of pain. Progress in Neurobiology 66, 355-474 (2002).

S.W. Evans and R.A. McCahon. Management of postoperative pain in maxillofacial surgery. British Journal of Oral and Maxillofacial Surgery 57, 4-11 (2019).

H. Trimmel et al. S(+)-ketamine. Current trends in emergency and intensive care medicine. Wiener klinische Wochenschrift 130, 356-366 (2018).

J.M. Riddell, J.M. Trummel and I.J. Onakpoya. Low-dose ketamine in painful orthopaedic surgery: a systematic review and meta-analysis. British Journal of Anaesthesia 123, 325-334 (2019).

F. Pincelli et al. Chlorhexidine with an Anti-Discoloration System. A comparative study. International Journal of Dental Hygiene 2, 122-126 (2004).

P. Cortellini et al. Chlorhexidine with an antidiscoloration system after periodontal flap surgery: a cross-over, randomized, triple-blind clinical trial. Journal of Clinical Periodontology 35, 614–620 (2008).

R. Baron, S. Ferrari and R.G.G. Russell. Denosumab and bisphosphonates: Different mechanisms of action and effects. Bone 48, 677-692 (2011).

B. Benjamin et al. Review on the comparison of effectiveness between denosumab and bisphosphonates in post-menopausal osteoporosis. Osteoporosis and Sarcopenia 2, 77-81 (2016).

P.K. Piper jr. and U. Gruntmanis. Management of osteoporosis in the aging male: Focus on zoledronic acid. Clinical Interventions in Aging 4, 289-303 (2009).

J.E. Dunford et al. Structure-Activity Relationships for Inhibition of Farnesyl

Diphosphate Synthase in Vitro and Inhibition of Bone Resorption in Vivo by Nitrogen-Containing Bisphosphonates. The Journal of Pharmacology and Experimental Therapeutics 296, 235-242 (2001).

L. Rejnmark, L. Underbjerg and T. Sikjaer. Therapy of Hypoparathyroidism by Replacement with Parathyroid Hormone. Scientifica, Article ID 765629 (2014).

M.T. Poldervaart et al. Treatment of Lymphatic Malformations with OK-432 (Picibanil): Review of the Literature. Journal of Craniofacial Surgery 20, 1158-1162 (2009).

M. Kono et al. Evaluation of OK-432 (Picibanil) injection therapy for intraoral ranula. International Journal of Oral and Maxillofacial Surgery 44, e249 (2015).

N. Efe et al. Excellent Result with the Use of Single-Dose OK-432 in Cervical Macrocystic Lymphangioma. Journal of Craniofacial Surgery 27, 1802-1803 (2016).

A. Weitz-Tuoretmaa et al. Efficacy of OK-432 sclerotherapy in treatment of lymphatic malformations: long-term follow-up results. European Archives of Oto-Rhino-Laryngology 271, 385-390 (2014).

Y. Safarpour and B. Jabbari. Botulinum toxin treatment of pain syndromes – an evidence based review. Toxicon 147, 120-128 (2018).

J. Pingel et al. Injection of high dose botulinum-toxin A leads to impaired skeletal muscle function and damage to the fibrilar and non-fibrilar structures. Nature Scientific Reports 7, 14746 (2018).

J. Jankovic. Botulinum Toxin: State of the Art. Movement Disorders 32, 1131-1138 (2017).

J. Jankovic. An update on new and unique uses of botulinum toxin in movement disorders. Toxicon 147, 84-88 (2018).

C. L. Comella. Systematic review of botulinum treatment for oromandibular dystonia. Toxicon 147, 96-99 (2018).

W. Photong et al. A case of dysphagia following botulinum toxin injection for neck rejuvenation. Journal of Cosmetic Dermatology 16, 15-17 (2016).

D. Tighe et al. Dysphagia as a complication of botulinum toxin injection to treat drooling. British Journal or Oral and Maxillofacial Surgery 52, 673-674 (2014).

A.J. Sidebottom, A.A. Patel and J. Amin. Botulinum injection for the management of myofascial pain in the masticatory muscles. A prospective outcome study. British Journal of Oral and Maxillofacial Surgery 51, 199-205 (2013).

S. Gregory et al. Nd:YAG laser and bleomycin sclerotherapy under the same anesthesia for cervicofacial venous malformations: A safe and effective treatment option. International Journal of Pediatric Otorhinolarnygology 108, 30-34 (2018).

A. Groselj et al. Efficiency of electrochemotherapy with reduced bleomycin dose in the treatment of nonmelanoma head and neck skin cancer: Preliminary results. Head & Neck 40, 120-125 (2018).

P.K. Porwal et al. Bleomycin Sclerotherapy in Lymphangiomas of Head and Neck: Prospective Study of 8 Cases. Indian Journal of Otolaryngology and Head & Neck Surgery 70, 145-148 (2018).

E.R.S. Horbach et al. Intralesional Bleomycin Injections for Vascular Malformations: A Systematic Review and Meta-Analysis. Plastic and Reconstructive Surgery 137, 244-256 (2016).

J.M. Mack et al. Short-term side effects and patient-reported outcomes of bleomycin sclerotherapy in vascular malformations. Paediatric Blood Cancer 65:e27008 (2018).

S.M. Hecht. Bleomycin: New Perspectives on the Mechanism of Action. Journal of Natural Products 63, 158-168 (2000).

M.G. Traber and J. Atkinson. Vitamin E, antioxidant and nothing more. Free Radical Biology and Medicine 43, 4-15 (2007).

Q. Jiang. Natural forms of vitamin E: metabolism, antioxidant, and anti-inflammatory activities and their role in disease prevention and therapy. Free Radical Biology and Medicine 72, 76-90 (2014).

F. Galli et al. Vitamin E: Emerging aspects and new directions. Free Radical Biology and Medicine 102, 16-36 (2017).

A. Azzi et al. The rise, the fall and the renaissance of vitamin E. Archives of Biochemistry and Biophysics 595, 100-108 (2016).

M.F. McCarty, J.H. O’Keefe and J.J. DiNicolantonio. Pentoxifylline for vascular health: a brief review of the literature. Open Heart 3:e000365 (2016).

W.X. Wen et al. Repurposing Pentoxifylline for the Treatment of Fibrosis: An Overview. Advances in Therapy 34, 1245-1269 (2017).

C.H. Lee, A. Singla and Y. Lee. Biomedical applications of collagen. International Journal of Pharmaceutics 221, 1-22 (2001).

N. Annabi et al. Elastic sealants for surgical applications. European Journal of Pharmaceutics and Biopharmaceutics 95A, 27-39 (2015).

M. Westberg et al. Effectiveness of Gentamicin-Containing Collagen Sponges for Prevention of Surgical Site Infection after Hip Arthroplasty: A Multicenter Randomized Trial. Clinical Infectious Diseases 60, 1752–1759 (2015).

F. Zamboni et al. The potential of hyaluronic acid in immunoprotection and immunomodulation: Chemistry, processing and function. Progress in Materials Science 97, 97-122 (2018).

M. Litwiniuk, A. Krejner and T. Grzela. Hyaluronic Acid in Inflammation and Tissue Regeneration. Wounds 28, 78-88 (2016).

H. Zhao et al. Comprehensive assessment of tranexamic acid during orthognathic surgery. A systematic review and meta-analysis of randomized, controlled trials. Journal of Cranio-Maxillo-Facial Surgery 47, 592-601 (2019).

Miscellaneous treatments

Textbooks

K. Nouri (ed.). Lasers in Dermatology and Medicine. Springer, 2018.

G. Stux and B. Pomeranz. Basics of Acupuncture (4^th ed.). Springer Science & Business Media, 2013.

H. MacPherson (ed.). Acupuncture Research: Strategies for Establishing an Evidence Base. Elsevier Health Sciences, 2007.

J. Filshie, A. White and M. Cummings (eds.). Medical Acupuncture: A Western Scientific Approach. Elsevier, 2016.

M.R. Hamblin, M.V. De Sousa and T. Agrawal. Handbook of Low Level Laser Therapy. Pan-Stanford Publishing, Singapore, 2016.

D. Ottoson and T. Lundeberg. Pain Treatment by Transcutaneous Electrical Nerve Stimulation (TENS): A Practical Manual. Springer Science & Business Media, 2012.

M.I. Johnson. Transcutaneous Electrical Nerve Stimulation (TENS): Research to Support Clinical Practice. Oxford University Press, Oxford, 2014.

M.S. Schwartz and F. Andrasik (eds.). Biofeedback: A Practitioner’s Guide (4^th ed.). Guildford Publications, 2017.

Journal articles (peer reviewed literature)

E. O’Sullivan and I. Higginson. Clinical effectiveness and safety of acupuncture in the treatment of irradiation-induced xerostomia in patients with head and neck cancer: a systematic review. Acupuncture in Medicine 28, 191-199 (2010).

M. Cummings, A. Hróbjartsson and E. Ernst. Should doctors recommend acupuncture for pain? British Medical Journal 360:k970 (2018).

R. la Touche et al. Acupuncture in the treatment of pain in temporomandibular disorders: a systematic review and meta-analysis of randomized controlled trials. The Clinical Journal of Pain 26, 541.550 (2009).

J. McDonald. Why Randomised Placebo-controlled Trials are Inappropriate for Acupuncture Research. Journal of Chinese Medicine 119, 47-54 (2019).

M.M. Makary et al. Phantom Acupuncture Induces Placebo Credibility and Vicarious Sensations: A Parallel fMRI Study of Low Back Pain Patients. Nature Scientific Reports 8, 930 (2018).

Y. Chae, Y.-S. Lee and P. Enck. How Placebo Needles Differ From Placebo Pills? Frontiers in Psychiatry doi.org/10.3389/fpsyt.2018.00243 (2018).

F.K. Allan et al. Acupuncture for anxiety in dental patients: Systematic review and meta-analysis. European Journal of Integrative Medicine 20, 22-35 (2018).

M.W.C. Chan et al. Safety of Acupuncture: Overview of Systematic Reviews. Nature Scientific Reports 7, 3369 (2017).

J.P. Epstein et al. Photobiomodulation therapy: management of mucosal necrosis of the oropharynx in previously treated head and neck cancer patients. Supportive Care in Cancer 25, 1031-1034 (2017).

J.A.E.M. Zecha et al. Low-level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 2: proposed applications and treatment protocols. Supportive Care in Cancer 24, 2793–2805 (2016).

F. Marín-Conde et al. Photobiomodulation with low-level laser therapy reduces oral mucositis caused by head and neck radio-chemotherapy: prospective randomized controlled trial. International Journal of Oral and Maxillofacial Surgery 48, 917-923 (2019).

M.R. Hamblin. Mechanisms and Mitochondrial Redox Signalling in Photobiomodulation. Photochemistry and Photobiology 94, 199–212 (2018).

V. Heiskanen and M.R. Hamblin. Photobiomodulation: lasers vs. light emitting diodes? Photochemical and Photobiological Sciences 17, 1003-1017 (2018).

Y. Zadik et al. Systematic review of photobiomodulation for the management of oral mucositis in cancer patients and clinical practice guidelines. Supportive Care in Cancer 27, 3969-3983 (2019).

M.T. Genot-Klastersky et al. Retrospective evaluation of the safety of low-level laser therapy/photobiomodulation in patients with head/neck cancer. Supportive Care in Cancer doi.org/10.1007/s00520-019-05041-3 (2019).

F. Alaijah et al. Photobiomodulation therapy in the treatment of periodontal disease: a literature review. Lasers in Dental Science 3, 147-153 (2019).

D.P. Kuffler. Platelet-Rich Plasma Promotes Axon Regeneration, Wound Healing and Pain Reduction: Fact or Fiction. Molecular Neurobiology 52, 990-1014 (2015).

J.S. Fernandez-Moure et al. Platelet-rich plasma: a biomimetic approach to enhancement of surgical wound healing. Journal of Surgical Research 207, 33-44 (2017).

K.M. Hassan and A.V. Benedetto. Facial skin rejuvenation: ablative laser resurfacing, chemical peels or photodynamic therapy? Facts and controversies. Clinical Dermatology 31, 737-740 (2013).

N. Nikalji et al. Complications of medium-depth and deep chemical peels. Journal of Cutaneous and Aesthetic Surgery 4, 254-260 (2012).

C.G. Wambier et al. Advanced chemical peels: Phenol – croton oil peel. Journal of the American Academy of Dermatology 81, 327-336 (2019).

S.J. Starkman and D.S. Mangat. Chemical Peels: Deep, Medium, and Light. Facial and Plastic Surgery 35, 239-247 (2019).

W. Mansukiatti, R.E. Fitzpatrick and M.P. Goldman. Long-term effectiveness and side effects of carbon dioxide laser resurfacing for photo-aged facial skin. Journal of the American Academy of Dermatology 40, 401-411 (1999).

T.M. Campbell and M.P. Goldman. Adverse events of fractionated carbon dioxide laser: review of 373 treatments. Dermatologic Surgery 36, 1645-1659 (2010).

H.G. Setyadi, A.A. Jacobs and R.F. Markus. Infectious complications after nonablative fractional resurfacing treatment. Dermatologic Surgery 34, 1595-1598 (2008).

A. Kauvar and J.S. Dover. Facial skin rejuvenation: laser resurfacing or chemical peel: choose your weapon. Dermatologic Surgery 27, 209-212 (2001).

B.-J. Kim et al. Laser Resurfacing after Facial Free Flap Reconstruction. Medical Lasers 8, 7-12 (2019).

K.A. Sluka and D. Walsh. Transcutaneous Electrical Nerve Stimulation: Basic Science Mechanisms and Clinical Effectiveness. The Journal of Pain 4, 109-121 (2003).

K.E. Nnoaham, J. Kumbang J. Transcutaneous electrical nerve stimulation (TENS) for chronic pain. Cochrane Database of Systematic Reviews 3:CD003222 (2008).

New developments

Textbooks

G.A. Grillone and S. Jalisi (eds.). Robotic Surgery of the Head and Neck: A Comprehensive Guide. Springer, New York, Heidelberg, 2015.

Z. Gil, M. Amit and M.E. Kupferman (eds.). Atlas of Head and Neck Robotic Surgery. Springer International Publishing, 2017.

M.L. Hinni and D.G. Lott (eds.). Contemporary Transoral Surgery for Primary Head and Neck Cancer. Plural Publishing, San Diego, 2015.

J.R. Ferraro and K. Nakamoto. Introductory Raman Spectroscopy. Academic Press, San Diego, 1994.

P. Larkin. IR and Raman Spectroscopy. Principles and Spectral Interpretation. Elsevier Inc., 2011.

M. Ghomi (ed.). Applications of Raman Spectroscopy to Biology. From Basic Studies to Disease Diagnosis. IOS Press, Amsterdam, Berlin, 2012.

J.H. Gross. Mass Spectrometry. A Textbook, 2^nd edition. Springer, Heidelberg, 2011.

M.S. Lee (ed.). Mass Spectrometry Handbook. John Wiley, Hoboken, 2012.

T. Liljefors, P. Kogsgaard-Larsen and U. Madsen. Textbook of Drug Design and Discovery, 3^rd edition. Taylor & Francis, 2003.

D.G. Truhlar, W.J. Howe, A.J. Hopfinger, J. Blaney and R.A. Dammkoehler (eds.). Rational Drug Design. Springer Verlag, Berlin, 1999.

R.C. Rees (ed.). Tumour Immunology and Immunotherapy. Oxford University Press, Oxford, 2014.

L.J.N. Cooper, E.A. Mittendorf, J. Moyes and S. Prabhakaran (eds.). Immunotherapy in Translational Cancer Research. Wiley-Blackwell, Oxford, 2018.

V.T. DeVita, T.S. Lawrence and S.A. Rosenberg (eds.). Cancer. Principles & Practice of Oncology, 10^th edition. Wolters Kluwer, Philadelphia, 2015.

A. Naing and J. Haijar (eds.). Immunotherapy, 2^nd edition. Springer International Publishers, 2018.

J.Z. Muller. The Tyranny of Metrics. Princeton University Press, Princeton, 2018.

J.L. Peacock and P.J. Peacock. Oxford Handbook of Medical Statistics. Oxford University Press, Oxford, 2011.

L.M. Friedman, C. Furberg and D.L. DeMets. Fundamentals of Clinical Trials, 4^th ed. Springer Science & Business Media, 2010.

T.D. Cook and D.L. DeMets. Introduction to Statistical Methods for Clinical Trials. CRC Press, 2007.

T. Brody. Clinical Trials. Study Design, Endpoints and Biomarkers, Drug Safety and FDA and ICH Guidelines. Academic Press, 2011.

W.F. Rosenberger and J.M. Lachin. Randomization in Clinical Trials: Theory and Practice, 2^nd ed. John Wiley & Sons, 2015.

R. Chin. Adaptive and Flexible Clinical Trials. CRC Press, 2016.

S. Halabi and S. Michiels (eds.). Textbook of Clinical Trials in Oncology: A Statistical Perspective. CRC Press, 2019.

G.T.J. Huang and I. Theslaff. Stem Cells in Craniofacial Development and Regeneration. John Wiley & Sons, 2013.

R. Lanza, J. Gearhart, B. Hogan, D. Melton, R. Pedersen, E.D. Thomas, J.A. Thomson and Sir I. Wilmut (eds.). Essentials of Stem Cell Biology (2^nd, revised ed.). Academic Press, 2009.

D.L. Nelson and M.M. Cox. Lehninger Principles of Biochemistry (7^th ed.). W.H.Freeman, 2017.

B. Alberts, K. Hopkin, A.D. Johnson, D. Morgan, M. Raff, K. Roberts and P. Walter. Essential Cell Biology (5^th international student ed.). W.W. Norton & Company, 2018.

Journal articles (peer reviewed literature)

D.H. Jensen et al. Mesenchymal stem cell therapy for salivary gland dysfunction and xerostomia: a systematic review of preclinical studies. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology 117, 335-342 (2014).

E.R. Vickers et al. A preliminary report on stem cell therapies for neuropathic pain in humans. Journal of Pain Research 7, 255-263 (2014).

D. Nevens and S. Nuyt. The role of stem cells in the prevention and treatment of radiation-induced xerostomia in patients with head and neck cancer. Cancer Medicine 5, 1147-1153 (2016).

G.T.-J. Huang, S. Gronthos and S. Shi. Mesenchymal Stem Cells Derived from Dental Tissue vs. Those from Other Sources: Their Biology and Role in Regenerative Medicine. Journal of Dental Research 88, 792-806 (2009).

G. Spagnuolo et al. Commitment of Oral-Derived Stem Cells in Dental and Maxillofacial Applications. Dentistry Journal 6:72 (2018).

V.S. Venkataiah et al. Periodontal Regeneration by Allogenic Transplantation of Adipose Tissue Derived Multi-Lineage Progenitor Stem Cells in vivo. Nature Scientific Reports 9, 921 (2019).

H. Lin et al. Bone marrow mesenchymal stem cells: Aging and tissue engineering applications to enhance bone healing. Biomaterials 203, 96-110 (2019).

J.-M. Lee et al. Developing palatal bone using human mesenchymal stem cells and stem cells from exfoliated deciduous teeth cell sheets. Journal of Tissue Engineering and Regenerative Medicine 13, 319-327 (2019).

M.T. Cerqueira, R.P. Pirraco and A.P. Marques. Stem Cells in Skin Wound Healing: Are We There Yet? Advances in Wound Care 5, 164-175 (2016).

A.R. Ahmadi et al. Stem cells in burn wound healing: A systematic review of the literature. Burns 45, 1014-1023 (2019).

H.T. Greinix et al. CD19+CD21^low B Cells and CD4+CD45RA+CD31+ T Cells Correlate with First Diagnosis of Chronic Graft-versus-Host Disease. Biology of Blood and Marrow Transplantation 21, 250-258 (2015).

A.Z. Ayob and T.S. Ramasamy. Cancer stem cells as key drivers of tumour progression. Journal of Biomedical Science 25:20 (2018).

R.L. Ferris. Immunology and Immunotherapy of Head and Neck Cancer. Journal of Clinical Oncology 33, 3293-3304 (2015).

R.L. Ferris et al. Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck. New England Journal of Medicine 375, 1856-1867 (2016).

T.L. Whiteside. Head and Neck Carcinoma Immunotherapy: Facts and Hopes. Clinical Cancer Research 24, 6-13 (2018).

M.V. Heppt et al. Intralesional interleukin-2 for unresectable mucosal melanoma refractory to nivolumab. Cancer Immunology and Immunotherapy 66, 1377-1378 (2017).

J.K. Tietze et al. Low baseline levels of NK cells may predict a positive response to ipilimumab in melanoma therapy. Experimental Dermatology 26, 622-629 (2017).

B. Weide et al. Baseline Biomarkers for Outcome of Melanoma Patients Treated with Pembrolizumab. American Association for Cancer Research, Clinical Cancer Research 22, 5487-5496 (2016).

T.K. Eigentler et al. Diagnosis, monitoring and management of immune-related adverse drug reactions of anti-PD1 antibody therapy. Cancer Treatment Reviews 45, 7-18 (2016).

L. Spain, S. Diem and J. Larkin. Management of toxicities of immune checkpoint inhibitors. Cancer Treatment Reviews 44, 51-60 (2016).

D.V. Bann, D.G. Deschler and N. Goyal. Novel Immunotherapeutic Approaches for Head and Neck Squamous Cell Carcinoma. Cancers 8, 87 (2016).

K. Schneider et al. Therapeutic human papillomavirus vaccines in head and neck cancer: A systematic review of current clinical trials. Vaccine 36, 6594-6605 (2018).

B. Samra et al. Checkpoint inhibitors in head and neck cancer: Current knowledge and perspectives. Journal of Investigative Medicine 66, 1023-1030 (2018).

T. Rusch et al. Immunotherapy as an Option for Cancer Treatment. Archivum Immunologiae et Therapiae Experimentalis 66, 89-96 (2018).

D.C. Ling et al. Role of Immunotherapy in Head and Neck Cancer. Seminars in Radiation Oncology 28, 12-16 (2017).

J. Cho., D.E. Johnson and J.R. Grandis. Therapeutic Implications of the Genetic Landscape of Head and Neck Cancer. Seminars in Radiation Oncology 28, 2-11 (2017).

N.A. Rizvi et al. Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science 348, 124–128 (2015).

C. Kandoth et al. Mutational landscape and significance across 12 major cancer types. Nature 502, 333–339 (2013).

B. Solomona, R.J. Young and D. Rischin. Head and neck squamous cell carcinoma: Genomics and emerging biomarkers for immunomodulatory cancer treatments. Seminars in Cancer Biology 52, 228-240 (2018).

Y. Yu and J. Cui. Present and future of cancer immunotherapy: A tumor microenvironmental perspective (Review). Oncology Letters 16, 4105-4113 (2018).

S. Jin, R. Pazdur and R. Sridhara. Re-Evaluating Eligibility Criteria for Oncology Clinical Trials: Analysis of Investigational New Drug Applications in 2015. Journal of Clinical Oncology 35, 3745-3753 (2017).

J.J. Havel, D. Chowell and T.A. Chan. The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy. Nature Reviews Cancer 19, 133-150 (2019).

G.J. Hanna et al. Frameshift events predict anti-PD-1/L1 response in head and neck cancer. The Journal of Clinical Investigation Insight 3, e98811 (2018).

P. Arnaud-Coffin et al. A systematic review of adverse effects in randomized trials assessing immune checkpoint inhibitors. International Journal of Cancer 145, 639-648 (2019).

E.J. Sayour and D.A. Mitchell. Manipulation of Innate and Adaptive Immunity through Cancer Vaccines. Journal of Immunology Research, 3145742 (2017).

M.A. Gadhikar and J.N. Myers. Recent advances in head and neck cancer: The beginning of the immunotherapy era in HNSCC. Advances in Modern Oncology Research 4, 284 (2018).

E. Vigarios, J.B. Epstein and V. Sibaud. Oral mucosal changes induced by anticancer targeted therapies and immune checkpoint inhibitors. Support Care Cancer 25, 1713-1739 (2017).

H.-F. Kao and P.-J. Lou. Immune checkpoint inhibitors for head and neck squamous cell carcinoma: Current landscape and future directions. Head & Neck 41, 4-18 (2019).

B.L. Rapoport et al. Supportive care for patients undergoing immunotherapy. Support Care Cancer 25, 3017-3030 (2017).

B.W. O’Malley jr. et al. Transoral robotic surgery (TORS) for base of tongue neoplasms. Laryngoscope 116, 1465-1472 (2006).

 J.R. de Almeida et al. Oncologic Outcomes after Transoral Robotic Surgery. A Multi-institutional Study. JAMA Otolaryngology Head and Neck Surgery 141, 1043-1051 (2015).

D.C. Ling et al. Oncologic outcomes and patient-reported quality of life in patients with oropharyngeal squamous cell carcinoma treated with definitive transoral robotic surgery versus definitive chemoradiation. Oral Oncology 61, 41-46 (2016).

S. Baliga et al. Utilization of Transoral Robotic Surgery (TORS) in patients with Oropharyngeal Squamous Cell Carcinoma and its Impact on Survival and Use of Chemotherapy. Oral Oncology 86, 75-80 (2018).

M.C. Ward and S.A. Koyfman. Transoral robotic surgery: The radiation oncologist’s perspective. Oral Oncology 60, 96-102 (2016).

B.G. Main et al. Protocol for the systematic review of the reporting of transoral robotic surgery. British Medical Journal Open 8:e019198 (2018).

K.C. Schäfer et al. In vivo, in situ tissue analysis using rapid evaporation ionization mass spectrometry. Angewandte Chemie International Edition 48, 8240-8242 (2009).

J. Balog et al. Intraoperative Tissue Identification Using Rapid Evaporative Ionization Mass Spectrometry. Science Translational Medicine 5, 194ra93 (2013).

B. Prideaux, A. Lenaerts and V. Dartois. Imaging and spatially resolved quantification of drug distribution in tissues by mass spectrometry. Current Opinion in Chemical Biology 44, 93-100 (2018).

M. Ji et al. Rapid, Label-Free Detection of Brain Tumors with Stimulated Raman Scattering Microscopy. Science Translational Medicine 5, 201ra119 (2013).

I.A. Birtoiu et al. Diagnosing clean margins through Raman spectroscopy in human and animal mammary tumour surgery: a short review. Interface Focus 6:20160067 (2016).

F.L.J. Cals et al. Investigation of the potential of Raman spectroscopy for oral cancer detection in surgical margins. Laboratory Investigations 95, 1186-1196 (2015).

E.M. Barroso et al. Discrimination between Oral Cancer and Healthy Tissue Based on Water Content Determined by Raman Spectroscopy. Analytical Chemistry 87, 2419-2426 (2015).

E.M. Barroso et al. Raman spectroscopy for assessment of bone resection margins in mandibulectomy for oral cavity squamous cell carcinoma. European Journal of Cancer 92, 77-87 (2018).

I.P. Santos et al. Raman spectroscopy for cancer detection and cancer surgery guidance: translation to the clinics. Analyst 142, 3025-3047 (2017).

M. Nieberler et al. Exploring the role of RGD-Recognizing Integrins in Cancer. Cancers 9, 116 (2017).

M. Nieberler et al. Fluorescence imaging of invasive head and neck carcinoma cells with integrin v6-targeting RGD-peptides: an approach to a fluorescence-assisted intraoperative cytological assessment of bony resection margins. British Journal of Oral and Maxillofacial Surgery 56 972–978 (2018).

F. Reichart et al. Selective Targeting of Integrin αvβ8 by a Highly Active Cyclic Peptide. Journal of Medicinal Chemistry 62, 2024-2037 (2019).

H.A. Haenssle et al. Man against machine: diagnostic performance of a deep learning convolutional neural network for dermoscopic melanoma recognition in comparison to 58 dermatologists. Annals of Oncology 29, 1836-1842 (2018).

M. Zwierzyma et al. Clinical trial design and dissemination: comprehensive analysis of clinicaltrials.gov and PubMed data since 2005. British Medical Journal 361, k2130 (2018).

A.B. Smith. Should we be taking the p (value) out of statistics? British Journal of Oral and Maxillofacial Surgery 55, 657-660 (2017).

A.B. Smith. Feel the power: sample size and meaningful effects. British Journal of Oral and Maxillofacial Surgery 56, 650-652 (2018).

N. Sanati et al. Network-Based Predictors of Progression in Head and Neck Squamous Cell Carcinoma. Frontiers in Genetics 9:183 (2018).

K. Litchfield et al. Representative Sequencing: Unbiased Sampling of Solid Tumour Tissue. Cell Reports 31, 107550 (2020).

V. Spahn et al. A nontoxic painkiller designed by modelling of pathological receptor conformations. Science 355, 966-969 (2017).

Photodynamic therapy

Textbooks

M.A. Biel (ed.) Photodynamic Therapy of Disease of the Head and Neck. Plural Publishing San Diego, 2008.

T. Patrice (ed.) Photodynamic Therapy. RSC, Cambridge, 2003.

M.R. Hamblin and P. Mroz (eds.) Advances in Photodynamic Therapy – Basic, Translational, and Clinical. Artech House, Boston London, 2008.

Journal articles (peer reviewed literature)

B. Green, A.R.M. Cobb and C. Hopper. Photodynamic therapy in the management of lesions of the head and neck.  British Journal of Oral and Maxillofacial Surgery 51, 283-287 (2013).

M.G. Bredell, E. Besic, C. Maake and H. Walt. The application and challenges of clinical PD–PDT in the head and neck region: A short review. Journal of Photochemistry and Photobiology B: Biology 101, 185-190 (2010).

R.R. Allison, R.E. Cuenca, G.H. Downie, P. Camnitz, B. Brodish and C.H. Sibata. Clinical photodynamic therapy of head and neck cancers – A review of applications and outcomes. Photodiagnosis and Photodynamic Therapy 2, 205-222 (2005).

S.B. Brown, E.A. Brown and I. Walker. The present and future role of photodynamic therapy in cancer treatment. The Lancet Oncology 5, 497-508 (2004).

F.J. Civantos et al. A Review of Photodynamic Therapy for Neoplasms of the Head and Neck. Advances in Therapy 35, 324-340 (2018).